This anime is based on the original Argentine graphic novel series of the same name. The narrative follows the titular character, a genetically engineered super-soldier and one of the products of Dr. Von Reichter's diabolic experiments. The fictional Von Reichter is actually a former Nazi who conducted horrendous experiments during the Second World War. He flees to South America, where he continues his experiments, which culminate in the creation of the "Cybers," one of whom is Cybersix. However, because the Cybers exhibit free will at a young age—an undesired trait—Von Reichter destroys all the Cybers to prevent a rebellion. In the present day, Cybersix is one of the Cybers who managed to escape and is living a quiet life under the alias "Adrian Seidelman." However, she discovers that her survival depends on a special substance created by Von Reichter, forcing her to hunt down the "Technos," a newer generation of super-soldiers created by him, in order to survive. Unintentionally, in the process, Cybersix becomes a superhero protecting the world from Dr. Von Reichter's creations and his evil plans.