Mister is a "coyote" or space-faring outlaw who has spent a year in prison for a traffic violation. Ten days before his release, he escapes with the assistance of his former partners, Bishop and Katana. He then tracks down Franka, who was left in his care by her deceased father, and takes her on a quest to locate her father's treasure. Pursuing them are federal investigators Angelica and Chelsea, along with the android assassins of the Criminal Guild, Madame Marciano's Twelve Sisters.