In a futuristic world, the Maruhage Empire is a militant organization intent on stealing everyone's hair, and thereby their freedom. However, a courageous man with a golden afro and steel nose hairs rises against their tyranny. Bobobo-bo Bo-bobo, trained in the ways of hair, rescues a teenager named Beauty from the grunts of the Maruhage Empire. Together, they embark on a journey to defeat Emperor Tsuru Tsurulina IV. As Bo-bobo makes new friends and battles foes along the way, he also begins his quest to save all the hairs of the world! Light-hearted and comical, Bobobo-bo Bo-bobo details a wacky adventure in which Bo-bobo and his companions fight all sorts of villains and deviants within the Maruhage Empire, all the while having a fun and exciting adventure.