Within a colossal steel maze infested with terrifying creatures, humanity is compelled to retreat into isolated enclaves, living in perpetual dread of extinction. In this dystopian setting, only a peculiar young man named Killy possesses the courage to venture through its merciless lands. Equipped with superhuman strength and a rare Graviton Beam Emitter, Killy battles bloodthirsty beasts and other fiendish forces in his desperate quest for a human possessing the Net Terminal Gene—genetic data that holds the potential to restore the corrupted world. The grim world of Blame! tracks Killy as he encounters new individuals, spills more blood, and draws nearer to locating the Net Terminal Gene. Through these endeavors, the true nature of the world is gradually revealed.