D.S.O. agent Leon S. Kennedy is on a mission to rescue Dr. Antonio Taylor from kidnappers, but a mysterious woman thwarts his pursuit. Meanwhile, B.S.A.A. agent Chris Redfield is investigating a zombie outbreak in San Francisco, where the cause of the infection remains unidentified. The only commonality among the victims is that they all recently visited Alcatraz Island. Following this clue, Chris and his team head to the island, where a new horror awaits them.