Each year, a class is randomly selected to be stranded in a deserted location, where they are compelled to kill one another to survive. Initially under the impression that they are on a graduation trip, Shuuya Nanahara and the other students of Class B at Shiroiwa Junior High discover they have been chosen to take part in this life-and-death contest known as The Program. Upon waking and realizing they are quarantined on an island, the 42 students find they have been fitted with metal collars that will detonate if specific conditions are not met. To gain their freedom, they must slaughter everyone else by any means necessary, with the final survivor declared the winner. As each class member pursues their own course, Shuuya sets his goal on leaving the island without participating in the game, aiming to put an end to this madness once and for all.