+Anima are rare, mysterious human-like beings who can transform their bodies into animal forms, yet they are shunned by human society. Cooro, a young orphaned +Anima with the abilities of a crow, struggles to find acceptance and a sense of belonging. Having been discovered on a church altar as an infant, he knows little about his origins or his species, despite the poor reputation they hold. Consequently, he resolves to search for others of his kind. Alongside his newfound companions—Husky, Nana Alba, and Senri—Cooro embarks on a quest to meet other outcasts and discover their place in an unforgiving world. As the bond between the four +Anima strengthens into an unbreakable tie throughout their travels, a sense of adventure seems everlasting. However, the group soon realizes that finding somewhere to belong might prove more challenging than previously anticipated. +Anima follows the hardships and adventures of Cooro and his friends as they learn about the difficulties and prejudice experienced by their kin.