Kiyoko

キヨコ

Kiyoko, designated #25, is the sole female among the Espers. She possesses green, wrinkled skin and long white hair arranged in braids, and she wears a pink nightgown; in the anime's flashback, Kiyoko has healthy skin and light brown hair, and is dressed in a pink gown. She is confined to bed due to her physical frailty, likely a consequence of the experiments and/or drugs, and is invariably seen lying down. It was she who foretold the collapse of Neo-Tokyo and Tetsuo's connection with Akira.
Kiyoko was probably an orphan when she was taken, along with a group of young children, by the government of the original Tokyo. At that time, the Japanese government was leading a secret project, overseen by Colonel Shikishima, to cultivate psychic abilities, potentially for military and political ends. This is where Kiyoko met and became friends with Takashi, Masaru, and Akira.
The project concluded when Akira became too powerful and ascended to a higher plane, leaving behind a psychic explosion that destroyed Tokyo. The survivors of this disaster founded Neo-Tokyo, while Kiyoko, Masaru, and Takashi, later known as the "Espers," were held in extended isolation to prevent information about the covert project from reaching the general public. The trio of children were continuously administered drugs to prevent them from growing as powerful as Akira, which caused premature aging while they were still young and led to physical disabilities; in Kiyoko's case, she eventually became so weak that she had to stay in bed, sustained by life support.
Kiyoko has a kind and gentle nature and cares for Takashi and Masaru as a mother would, often worrying about their welfare. She acts as the leader of the Espers regarding final decisions, and because of her abilities, she is very wise and perceptive, which is why her friends and even the Colonel seek her advice on future actions. She believes that every person has a destiny, and thus feels responsible for ensuring its fulfillment.