Dan was Shizune's uncle, specifically the younger brother of one of her parents. Following the death of his younger sister, he started campaigning for medical ninja to be assigned to every ninja squad. Tsunade held a similar view, and the two soon began dating on account of this shared belief. While they were together, Dan told Tsunade about his dream of becoming Hokage, desiring the title so he could more effectively protect Konoha's villagers. Dan was subsequently fatally injured during the Second Great Shinobi World War, and despite Tsunade's efforts to save him, he died from his wounds.
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